Small Crowders Slow Down Kinesin-1 Stepping by Hindering Motor Domain Diffusion
نویسندگان
چکیده
منابع مشابه
Motor domain phosphorylation modulates kinesin-1 transport.
Disruptions in microtubule motor transport are associated with a variety of neurodegenerative diseases. Post-translational modification of the cargo-binding domain of the light and heavy chains of kinesin has been shown to regulate transport, but less is known about how modifications of the motor domain affect transport. Here we report on the effects of phosphorylation of a mammalian kinesin mo...
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ژورنال
عنوان ژورنال: Physical Review Letters
سال: 2015
ISSN: 0031-9007,1079-7114
DOI: 10.1103/physrevlett.115.218102